In HIV-infected patients, intestinal bacteria-derived products interfere with CD4<sup>+</sup>T cell regeneration

Despite successful suppression of viral replication by antiretroviral drugs there is no significant increase in the number peripheral CD4 + T lymphocytes some HIV-infected patients (immune nonresponse to therapy). One crucial factors for immunodeficiency aggravation immune activation developing response bacterial products entry into bloodstream through damaged intestinal barrier. Additionally, microflora produces various solutes that accumulate blood and exhibit toxic properties. This work aimed evaluate effect microbial (para-cresol sulfate indoxyl sulfate) on receiving therapy. The object study was subjects with different system restoration efficiency during Uninfected donors were enrolled as healthy controls. Plasma concentrations IL-6 (p = 0.012), IP-10 0.0004), sCD14 0.003) nonresponders increased compared those individuals effective Tcells responders). Although both groups HIV-positive did not differ plasma lipopolysaccharide I-FABP levels, para-cresol 0.001) 0.042) non-responders. In vitro experiments showed a negative dose-dependent viability mitotic activity lymphocytes. Thus, impaired regeneration therapy, higher level systemic inflammation noted than responding treatment an cells. severity barrier damage load components released are approximately same recovery treatment. Simultaneously, non-responders significantly enriched origin: sulfate. decrease proliferative capacity cells stimulated induction their death presence these toxins may be reason ineffective